Imaging Data

Until timepoint 36months, AIBL subjects with MR and PET imaging data constitute about 25% of the full AIBL cohort. At 54months, the image database was enriched with 250 MR/Flutemetamol, 200 MR/Florbetapir and 50 MR/PIB. Imaging data (MR and PET) are provided through the LONI Image Data Archive (IDA).

MR images

The MR data are provided in DICOM format. Only raw data are provided; no processed images or analysed results are provided.

ADNI-compliant Series only are provided. These are:

  • MPRAGE_ADNI_confirmed
  • AAxial_PD-T2_TSE_confirmed

and for 54months, ADNI-compliant Series are:

  • MPRAGE_ADNI_confirmed
  • Space_3D_T2_FLAIR_sag_p2

Some of the oldest baseline AIBL data was acquired without ADNI-compliant Series and these data are not provided. There are both 3T and 1.5T data.

PET/PIB images

Generally, 6 frames each of 5min are acquired, starting at 40min after injection of the PIB biomarker. However, some early data were acquired with 10min frames.

To be compliant with ADNI, the images have been re-summed (no inter-frame registration) starting with the first frame consistent with a start time of 50min after injection of the PIB biomarker. Provided there is a minimum of 15min of data available to sum, all remaining frames are then summed, even if they extend beyond the 70min window (as this provides the best signal-to-noise ratio possible in the images). Images with less than 15min of data consistent with the 50-70min window are not provided.

The metadata describing the PET images is supplied in the table aibl_pibmeta.csv (available via the non-imaging download page. The following items should be noted (see also this table).

  • The element PBNMFRAM1 gives the total number of frames that were summed when available
  • The element PBDURATN1 gives the duration (in sec) of individual frames included in the sum

Florbetapir PET images

Generally, 3 frames each of 5min are acquired, starting at 50min after injection of the biomarker. The meta-data describing the PET images is supplied in the table aibl_AV45meta.csv (available via the non-imaging download page. The following items should be noted (see also this table).

  • The element PBNMFRAM1 gives the total number of frames that were summed when available
  • The element PBDURATN1 gives the duration (in sec) of individual frames included in the sum

Flutemetamol PET images

Generally, 4 frames each of 5min are acquired, starting at 90min after injection of the biomarker. The meta-data describing the PET images is supplied in the table aibl_flutemeta.csv (available via the non-imaging download page. The following items should be noted (see also this table).

  • The element PBNMFRAM1 gives the total number of frames that were summed when available
  • The element PBDURATN1 gives the duration (in sec) of individual frames included in the sum

Metadata

Users should not rely on the DICOM headers of any downloaded image data for correct subject metadata such as date of birth, age and gender. Users should always refer to the values in the non-imaging tables (e.g. demographics) supplied in the non-imaging page. However, the subject metadata (age, gender) available through the LONI/IDA query interface are correct.